Huang R, Ning H, Shen M, Li J, Zhang J, Chen X. Probiotics for the treatment of atopic dermatitis in children: a systematic review and meta-analysis of randomized controlled trials. Front Cell Infect Microbiol 2017;7:392. [ PubMed abstract] And there's likely to be a huge difference between the pharmaceutical-grade probiotics that show promise in clinical trials and the yoghurts and supplements sold in shops. Didari T, Solki S, Mozaffari S, Nikfar S, Abdollahi M. A systematic review of the safety of probiotics. Expert Opin Drug Saf 2014;13:227-39. [ PubMed abstract] Zhuang X, Xiong L, Li L, Li M, Chen M. Alterations of gut microbiota in patients with irritable bowel syndrome: A systematic review and meta-analysis. J Gastroenterol Hepatol 2017;32:28-38. [ PubMed abstract]

ProVen Probiotics ProVen Probiotics

Probiotics are identified by their specific strain, which includes the genus, the species, the subspecies (if applicable), and an alphanumeric strain designation [ 3]. The seven core genera of microbial organisms most often used in probiotic products are Lactobacillus, Bifidobacterium, Saccharomyces, Streptococcus, Enterococcus, Escherichia, and Bacillus. Table 1 shows examples of the nomenclature used for several commercial strains of probiotic organisms. Table 1: Nomenclature for sample commercial strains of probiotics [ 3] Genus Individuals receiving inpatient care are at significantly greater risk of developing AAD than individuals receiving outpatient care. Similarly, children younger than 2 years and seniors older than 65 years are at greater risk of developing AAD than other children and adults. Some antibiotics (e.g., erythromycin and penicillin) are associated with AAD more often than others [ 25, 26]. Probiotics also exert health effects by nonspecific, species-specific, and strain-specific mechanisms [ 1]. The nonspecific mechanisms vary widely among strains, species, or even genera of commonly used probiotic supplements. These mechanisms include inhibition of the growth of pathogenic microorganisms in the gastrointestinal tract (by fostering colonization resistance, improving intestinal transit, or helping normalize a perturbed microbiota), production of bioactive metabolites (e.g., short-chain fatty acids), and reduction of luminal pH in the colon. Species-specific mechanisms can include vitamin synthesis, gut barrier reinforcement, bile salt metabolism, enzymatic activity, and toxin neutralization. Strain-specific mechanisms, which are rare and are used by only a few strains of a given species, include cytokine production, immunomodulation, and effects on the endocrine and nervous systems. Through all of these mechanisms, probiotics might have wide-ranging impacts on human health and disease.For individuals with compromised immune function or other serious underlying diseases, the World Gastroenterology Organisation (WGO) advises restricting probiotic use to the strains and indications that have proven efficacy [ 3]. Probiotic Selection and Use

A Healthy Gut for a Healthy Life Concentrated - Probiotics

Side effects of probiotics are usually minor and consist of self-limited gastrointestinal symptoms, such as gas. In a few cases, mainly involving individuals who were severely ill or immunocompromised, the use of probiotics has been linked to bacteremia, fungemia (fungi in the blood), or infections that result in severe illness [ 69, 70]. However, some case reports did not confirm that the specific strain of probiotics used was the cause of the infection. In other cases, the probiotic strain used was confirmed to be the opportunistic pathogen. Because species used as probiotics can be normal residents of a patient’s microbiota, such confirmation is important. Didari T, Mozaffari S, Nikfar S, Abdollahi M. Effectiveness of probiotics in irritable bowel syndrome: Updated systematic review with meta-analysis. World J Gastroenterol 2015;21:3072-84. [ PubMed abstract] ProVen Probiotics Adult Acidophilus & Bifidus – 25 Billion is a high-strength friendly bacteria supplement for everyday use for adults aged 16+. Supported by a unique body of UK-based clinical research, the Lab4 live bacteria in ProVen Adult 25 Billion is the most comprehensively studied group of friendly bacteria in the UK.

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Antibiotics are another common cause of acute-onset diarrhea. Antibiotic treatment often disturbs the intestinal microbiome and, by decreasing microbial diversity, can lead to a loss of microbial metabolism (resulting in osmotic diarrhea due to excessive fluid in the intestine), loss of colonization resistance (resulting in increased numbers of infections by other pathogens), and increased intestinal motility [ 25]. Up to 30% of patients who use antibiotics experience AAD [ 26]. Each one-a-day capsule contains 17.5 billion live bacteria, combining the Lab4 consortium of bacteria with Lactobacillus gasseri. Each capsule also contains cranberry extract and vitamin B6, which contributes to the regulation of hormonal activity. Key features Because effects of probiotics can be specific to certain probiotic species and strains, recommendations for their use in the clinic or in research studies need to be species and strain specific [ 3, 5, 6]. Furthermore, pooling data from studies of different types of probiotics can result in misleading conclusions about their efficacy and safety. Sources of Probiotics Food

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Ortiz-Lucas M, Tobias A, Saz P, Sebastian JJ. Effect of probiotic species on irritable bowel syndrome symptoms: A bring up to date meta-analysis. Rev Esp Enferm Dig 2013;105:19-36. [ PubMed abstract] Munoz P, Bouza E, Cuenca-Estrella M, Eiros JM, Perez MJ, Sanchez-Somolinos M, et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 2005;40:1625-34. [ PubMed abstract] Ki Cha B, Mun Jung S, Hwan Choi C, Song ID, Woong Lee H, Joon Kim H, et al. The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Gastroenterol 2012;46:220-7. [ PubMed abstract] Zhao M, Shen C, Ma L. Treatment efficacy of probiotics on atopic dermatitis, zooming in on infants: a systematic review and meta-analysis. Int J Dermatol 2018;57:635-41. [ PubMed abstract] Probiotics are live bacteria and yeasts promoted as having various health benefits. They're usually added to yoghurts or taken as food supplements, and are often described as "good" or "friendly" bacteria.Food and Drug Administration. Policy regarding quantitative labeling of dietary supplements containing live microbials: Guidance for industry . 2018. Probiotics are generally classed as food rather than medicine, which means they don't go through the rigorous testing medicines do. American Gastroenterological Association. Consideration for use of probiotics in gastrointestinal diseases: clinical decision support tool. Gastroenterology 2020; 159: 706. [ PubMed abstract] Our digestive system (gut) is central to supporting our health – it contains more than 70% of the body’s immune system and 10 times more bacteria than we have cells in our whole body (the gut microbiome). Zmora N, Zilberman-Schapira G, Suez J, Mor U, Dori-Bachash M, Bashiardes S, et al. Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features. Cell 2018;174:1388-405.e21. [ PubMed abstract]