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León-López A, Morales-Peñaloza A, Martínez-Juárez VM, Vargas-Torres A, Zeugolis DI, Aguirre-Álvarez G. Hydrolyzed collagen—sources and applications. Molecules. 2019;24(22):4031. doi:10.3390/molecules24224031
There is strong evidence that shows marine collagen can be more effective in aiding joint and skin health. In general, however, marine collagen has not been shown to be more effective than most other products for other collagen needs.Tissue engineering is a biomedical engineering discipline that can replace or repair defective tissues with natural or synthetic tissue mimics. It aims to develop biological substitutes to replace, restore, or regenerate damaged tissues. Scaffolds, cells and growth-stimulating signals are the important components of engineered tissues. Scaffolds that are usually made of polymeric biomaterials can be used as an artificial structure to support three-dimensional (3D) tissue formation. They can provide structural support for subsequent tissue development and cell attachment [ 55]. Perhaps best known for its benefits to your skin and overall beauty, collagen, derived from the Greek word for glue, "Kólla", is the most abundant protein in our bodies. It plays a vital role in strengthening connective tissues and holding everything together. Found primarily in the skin, bones, tendons, and other connective tissues, collagen is essential for maintaining their health and integrity. However, as we age, our ability to produce collagen decreases, which contributes to the development of wrinkles and other signs of aging. Why choose Healthspan's Marine Collagen? Yang FC, Zhang Y, Rheinstädter MC. The structure of people's hair. PeerJ. 2014;2:e619. doi:10.7717/peerj.619 Aguirre-Cruz G, León-López A, Cruz-Gómez V, Jiménez-Alvarado R, Aguirre-Álvarez G. Collagen hydrolysates for skin protection: Oral administration and topical formulation. Antioxidants (Basel). 2020;9(2):181. doi:10.3390/antiox9020181
Our Hydrolysed Marine Collagen is derived from wild fish such as Cod (Gadidae) that are sourced in an environmentally-friendly and sustainable way from various regions across the world (EU, South America, Southeast Asia). Our hydrolysed collagen has NO artificial colours and flavours; and NO excipients, binders or fillers -- only pure and active ingredients. Hydrolyzed collagen provides many more benefits than any other type of collagen supplement because of the hydrolyzation of the collagen proteins. This means the proteins are broken down into smaller particles. These particles are much easier for the body to absorb. Sugihara F, Inoue N, Venkateswarathirukumara S. Ingestion of bioactive collagen hydrolysates enhanced pressure ulcer healing in a randomized double-blind placebo-controlled clinical study. Sci Rep. 2018;8(1):11403. doi:10.1038/s41598-018-29831-7 When the body can absorb the collagen easier, it allows more of the substance to be utilized by the body. Adding these hydrolyzed collagen supplements to a person’s daily supplement routine can provide benefits for people of all ages. The collaged-based treatments for skin regeneration, bone defects, periodontal disease, GERD, OA and RA have been discussed in Section 3, respectively. The association between some of these diseases has been investigated in the literature. RA was associated with skin disease. Dermatologic involvement usually occurred in patients with more severe RA [ 130]. Cutaneous manifestations might have a notable negative impact on the emotional, physical, and psychosocial health of RA patients [ 131]. Knowing the cutaneous expressions of RA may lead to early diagnosis, timely treatment, and lower morbidity for the patients [ 132]. Mesenchymal stem cells (MSCs) have been studied as a treatment for OA. Exosomes isolated from various stem cells may help tissue regeneration in the skin and inhibit the development of OA [ 133]. The prevalence of comorbidities among female patients with generalized OA was investigated [ 134]. Female patients with hand and knee OA were invited to participate in the study including two hundred generalized OA and two hundred control participants. GERD was observed to be one of the comorbidities of generalized OA. A 55-year-old female patient with endosseous dental implants had GERD and OA [ 135]. A possible connection between GERD and RA was discussed [ 136]. Miura et al. conducted a study to explore the relationship between RA and GERD. Two hundred and eleven patients in Japan were studied. The prevalence of GERD in RA patients was significantly higher than that in the Japanese population [ 137]. The prevalence of GERD symptoms in RA patients was high, and it is closely related to decreased functional status [ 138]. A total of 1147 patients with RA and 5735 controls were included in a study to investigate the association between RA and OA [ 139]. All participants were retrospectively traced, up to 14 years. Multivariate logistic regression analyses showed that patients with symptomatic OA had a significantly higher risk of RA. The high prevalence of secondary OA in patients with RA was determined in the trial [ 140].There are many types of collagen products on the market. These supplements often contain one of two types of collagen: hydrolyzed and marine. It is important for individuals who are considering collagen supplements to make an informed decision on which product is best for them. National Center for Biotechnology Information. PubChem Compound Summary for CID 656852, Glycyrrhizinate Dipotassium. Read more: Shop The Best Beauty Advent Calendars 2023 Has To Offer Which collagen is best type 1, 2 or 3? Wondering what exactly marine collagen is? Perhaps you know what it is, but you're not sure what it can do for you. In other words, what are the health benefits of hydrolyzed marine collagen peptides? Marine collagen, which comes exclusively from fish, has numerous health benefits, especially beauty benefits. These include helping to reduce the appearance of wrinkles and scars, possibly helping in stabilizing blood sugar, reducing inflammation, and so much more. Marine collagen is easily absorbed and highly effective. It's here to help you fight aging from the inside out. It's also great for pescetarians too! Here we provide everything you need to know about what is marine collagen: where it comes from and 8 amazing marine collagen benefits. What is Marine Collagen? Collagen is the most abundant protein in our body, yet our bodies produce less and less of it with each passing year. Since most of us don’t get enough collagen through our diets, supplementing with a quality source of collagen peptides is essential to keeping our bodies strong and healthy. This is where Marine Collagen Peptides can help. There are lots of marine collagen peptides benefits. Collagen peptides can come from different sources, including bovine and other animals. Marine Collagen Peptides are derived entirely from fish collagen, either fish skin or scales. The unique composition and structure of Marine Collagen Peptides provide numerous health benefits as explained below. 1. Marine collagen is highly bioavailable One marine collagen benefit is that it has superior absorption and bioavailability. Marine collagen has the smallest particle size and lowest molecular weight among all collagen types, which allows it to pass through the intestinal wall into the bloodstream more easily to provide better healing, repair, and nourishment. Marine collagen is absorbed up to 1.5 times more efficiently than other types of collagen, making it one of the best and effective types of collagen. 2. Type 1 Collagen Another marine collagen peptides benefit is that it is predominantly made up of Type 1 Collagen. There are over forty different types of collagen throughout the body that vary in their composition and function, but Type 1 collagen is the most abundant collagen in our body. Marine collagen consists almost entirely of Type 1 collagen, which is an important component of skin, bone, teeth, muscles, tendons, ligaments, and fascia. Some Marine Collagens, like Further Food Premium Marine Collagen, also contain Types 2 and 3 collagen, which can provide skin and joint benefits. 3. Rich in the amino acids glycine and proline An important marine collagen benefit is that it provides 8 out of 9 essential amino acids, including substantial amounts of glycine and proline which perform important functions throughout the body. Glycine is an all-encompassing amino acid that promotes the building of lean muscle mass, impacts the central nervous system to prevent the formation of stomach ulcers, has anti-inflammatory and antioxidant properties, and improves glucose tolerance to protect against diabetes. Proline is important for stimulating collagen synthesis and works as an antioxidant by scavenging free radicals to prevent cell damage. 4. It's environmentally friendly A marine collagen benefit that you might not know is that marine collagen is the most environmentally sustainable source of collagen. An estimated 60% of by-products of fish processing become waste 1 , but researchers recently discovered that these by-products, especially the collagen-rich fish skin, have amazing health-boosting properties. Additionally, marine collagen made from fish skin helps to reduce environmental pollution, and provides a superior and beneficial source of collagen protein. . Marine Collagen Benefits For Health and Beauty As we age, our body’s ability to produce new collagen declines, and existing collagen begins to break down. This loss of collagen is the root of aging of our skin, joints and bones, and this diminished supply can lead to increased digestive problems, a weakened immune system, and increased risk of chronic illness. Fortunately, science has shown that collagen supplementation may protect against and reverse these effects. There are lots of benefits of marine collagen powder. Here are 8 benefits of marine collagen supplements: 1. BUILDS BONE STRENGTH The loss of bone mass is one of the most common signs of aging and can lead to osteoporosis, which affects over 75 million people throughout the U.S., Europe, and Japan. Making sure we have enough calcium and phosphorus is essential to maintaining bone strength. However, these minerals are difficult to absorb, resulting in deficiencies and putting us at risk for bone loss and bone disease. Studies have shown that marine collagen peptides may help the absorption of calcium and other minerals that are essential for bone strength 2 . Additionally, marine collagen supplementation may stimulate collagen synthesis in the bones by promoting bone-building cells, called osteoblasts, 3 that build the organic matrix of bone, which is 90% collagen. 2. MAY HELP SLOW AGING The collagen in our skin begins breaking down at age 21 and continues to be degraded throughout adulthood, leading to saggy, wrinkly skin as we get older. 70% of our skin is made of Type 1 collagen, and supplementing with Marine Peptides, which are a Type 1 collagen, may help to replenish our skin and may even help to reverse aging. Clinical trials have shown patients who supplement with marine collagen have a decrease in wrinkles and improved skin hydration and firmness. 4,5 3. HIGH LEVELS OF GLYCINE WHICH HELPS SUPPORT BLOOD SUGAR LEVELS Marine collagen has a unique amino acid composition with higher glycine levels than any other types of collagen. Scientists are continuing to discover the beneficial roles of glycine throughout the body, specifically in relation to supporting healthy blood sugar levels. Recent research has found a connection between low blood glycine levels and impaired glucose tolerance, which suggests low glycine may lead to insulin resistance and ultimately diabetes. In fact, a 2016 study by the Alberta Diabetes Institute found consistently low levels of circulating glycine among people with type 2 diabetes. 6 4. MAY HELP LOWER CHOLESTEROL LEVELS Marine collagen supplementation has been shown in clinical trials to lower LDL (the bad lipoprotein) and increase HDL (the good lipoprotein) 7 . HDL is the “good” lipoprotein that pulls cholesterol and triglycerides out of the blood and tissues to help prevent tissue damage caused by fats. It is believed that marine collagen peptides may help promote genetic factors that regulate lipid metabolism and control cholesterol levels. 5. MAY HELP IMPROVE WOUND HEALING & REDUCES SCARS Do you know big Phama are behind shampoos, make up and lots of other health products ? Like Shampoos for example, they say X on the front like Collagen shampoo and it has like 1% in it and 40 other unknown chemicals. How is that not illegal ? is the MHRA (UK Gov) on Big Pharma pay roll ? ........
Bovine collagen is developed from cows. This form of collagen has some benefits over marine collagen. It has been shown to have increased abilities to prevent bone loss. It is also shown to have more improved results when used to reduce the signs of aging in the skin. Gingival recession (GR) is the exposure of root surfaces that is caused by apical migration of the gingival tissue margins and is frequently detected in adults [ 96]. The reference therapy for GR is the connective tissue graft (CTG) plus coronally advanced flap (CAF). Collagen bioscaffold was used for the treatment of GR [ 97]. For GR, cell adhesion in the scaffold influences the integration, migration, and survival of the cells among the scaffold. Collagen was found to be a superior bioscaffold for the treatment in GR. In a prospective randomized, controlled 18 adult patients clinical trial, a porcine collagen matrix plus CAF treatment showed no statistically significant differences compared with the CTG plus CAF treatment evaluated at 12 months [ 98]. As a result, the collagen matrix could be a possible alternative to CTG. Moreover, due to aging or disease, dentinal collagen undergoes glucose-related crosslinking. However, it remains unknown how collagen crosslinking affects the early adhesion of related oral streptococci. Schuh et al. studied the effect of glycated collagen on oral streptococcal nanoadhesion to help develop a new preventive and therapeutic treatment against dental caries [ 99]. Meanwhile, Logan recommends opting for type 1. “Type 1 collagen makes up 90 per cent of the collagen in the body, so it is certainly the one we should try and focus on the most – especially when looking to support the skin. Type 1 collagen is concentrated around the skin, bones, tendons and ligaments, helping to provide structure and strength.” Which collagen is best for anti-ageing? Further Food Marine Collagen Peptides completely dissolves in cold or hot liquids. Mix it into your daily coffee, smoothies, oatmeal, salad dressings, soup, pancake batter and more! Marine collagen has been shown to help calcium absorption and other minerals that are key for bone strength. Consuming marine collagen can help support healthy blood sugar levels, lower cholesterol levels, and reduce inflammation. Marine collagen also has antibacterial properties and may help with fighting infection. It's perfect for promoting weight loss and appetite suppression.The term, sarcopenia, was first introduced to refer to muscle wasting of older people [ 72]. And then in 2010, the definition of sarcopenia was altered to be low muscle mass together with low muscle function [ 73]. A patient can be diagnosed as sarcopenia when he/she has a slow walking speed and has muscle mass at least two standard deviations below the average [ 74]. There are age-related sarcopenia (primary sarcopenia) and disease-related sarcopenia (secondary sarcopenia). The causes of age-related sarcopenia included systemic inflammation, loss of motor units innervating muscle, a decline in anabolic hormones, and oxidative stress [ 73]. Early diagnosis and lifestyle intervention are the keys to improving the prognosis of patients with sarcopenia. The lifestyle interventions include exercise and nutritional supplements. In nutritional supplements, collagen supplements are effective to improve the symptoms of sarcopenia.
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