Treatment should be reserved for infants with clear evidence of a clinically significant patent ductus arteriosus (PDA). If your child is already taking any other medicines you should get advice from your pharmacist before giving them Calprofen as well.

Very rare: Acute renal failure, papillary necrosis, especially in long-term use, associated with increased serum urea and oedema. If you have asthma, symptoms such as wheeze or breathlessness can be made worse by anti-inflammatories such as ibuprofen. If this happens to you, you should stop taking ibuprofen and see your doctor as soon as possible. For Juvenile Rheumatoid Arthritis (prescription only use): Doses up to 30- 40mg/kg/day may be taken in three or four divided doses. Anadin®, Brufen®; Calprofen®; Cuprofen®; Fenpaed®; Feminax ®; Flarin ®; Ibucalm®; Noubid ®; Nurofen® If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work.Anti-platelet agents and selective serotonin reuptake inhibitors (SSRIs): increased risk of gastrointestinal bleeding (see section 4.4)

Very rarely, NSAIDS may cause serious blistering or peeling skin reactions (eg Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis). For this reason, you should stop using this medicine and consult your doctor if your child gets a skin rash or sores inside the mouth after taking this medicine. You'll usually give your child ibuprofen 3 or 4 times a day. Your pharmacist or doctor will tell you how often to give it. Monitor blood counts, renal, and hepatic function periodically for patients receiving long-term therapy. Where GI bleeding or ulceration occurs in patients receiving Ibuprofen, the treatment should be withdrawn. Zidovudine: Increased risk of haematological toxicity when NSAIDs are given with zidovudine. There is evidence of an increased risk of haemarthroses and haematoma in HIV(+) haemophiliacs receiving concurrent treatment with zidovudine and ibuprofen.

Usual Adult Dose for Pain

If your child's symptoms persist despite giving them Calprofen, get medical advice from your doctor or pharmacist. have or have had asthma, diabetes, high cholesterol, high blood pressure, a stroke, heart, liver, kidney or bowel problems Relieving aches, pains, fever and general discomfort associated with coldsand fluorfollowing childhood vaccinations.

The elderly have an increased frequency of adverse reactions to NSAIDs, especially gastrointestinal bleeding and perforation, which may be fatal. The adverse drug reactions (ADRs) observed in patients treated with ibuprofen are listed below by System Organ Class. Frequencies are defined in accordance with current guidance as: Very common (≥1/10); common (≥1/100 to<1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000), not known frequency (cannot be estimated from the available data). Ibuprofen is also available as creams, gels and sprays that are applied to the skin to relieve muscle and joint pain: Cuprofen gelAdvil®; Alivio®; Aprofen®; Cedaprin®; CounterAct® IB; Dolex®; Dragon Tabs®; Flex-Prin®; Ibutab®; Motrin® IB; Probufen®; Profen® IB; Proprinal® Very rare: Severe forms of skin reactions such as bullous reactions, including Stevens-Johnson Syndrome, erythema multiforme and toxic epidermal necrolysis can occur. Careful consideration should also be exercised before initiating long-term treatment of patients with risk factors for cardiovascular events (e.g. hypertension, hyperlipidaemia, diabetes mellitus, smoking), particularly if high doses of ibuprofen (2400 mg/day) are required. Ibuprofen is a common painkiller for children. It's often used to treat symptoms of conditions such as colds, flu and coronavirus (COVID-19), teething, toothache, headaches, sore throat and pain from ear infections. Severe forms of skin reactions such as bullous reactions, including Stevens- Johnson Syndrome, Erythema multiforme and Toxic Epidermal Necrolysis can occur